Yes. It will take any version of San Andreas that's not 1.0 (Minus Steam/D2D 3.0) and make it a 1.0 exe so you will be able to mod everything. I've personally used it on one of my retail copies and it works fine.
I want to request that Radio stations (RadioX,K-DST,etc...) be put in cop cars in MTA:SA. If someone found out how to mod it to add radio stations to Cop cars please email me at [email protected] (must work with MTA)
Thanks!